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KMID : 0043320050280121341
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1341 ~ p.1344
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Potent in Vitro Anticancer Activity of Metacycloprodigiosin and Undecylprodigiosin from a Sponge-Derived Actinomycete Saccharopolyspora sp. nov.
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Liu Rui
Cui Cheng Bin
Duan Lin
Gu Qian-Qun
Zhu Wei-Ming
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Abstract
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Bioassay-guided fractionation of extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
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KEYWORD
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Mycale plumose, Sponge-derived actinomycete, Saccharopolyspora sp. nov, Metacycloprodigiosin, Undecylprodigiosin, Tripyrrole pigments, Cytotoxicity
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